|
KMID : 0984720030350020091
|
|
Infection and Chemotherapy
2003 Volume.35 No. 2 p.91 ~ p.98
|
|
|
In vitro Antimicrobial Susceptibility of Carbapenems, Including Panipenem, against Clinical Isolates in Korea
|
|
Lee Dong-Gun
Kim Myung-Shin
Kang Jin-Han
Chun Hye-Sun
Choi Su-Mi
Wie Seong-Heon
Kim Sang-Il
Choi Jung-Hyun
Yoo Jin-Hong
Shin Wan-Shik
Kang Moon-Won
|
|
|
Abstract
|
|
|
Background: Panipenem (PAPM) is a new carbapenem which has an enhanced broad spectrum against both gram-positive and negative organisms. The aim of study was to compare the activities of PAPM with those of imipenem (IMPM), meropenem (MRPM) against several clinical isolates in Korea.
Methods: We tested the in vitro antimicrobial activities of PAPM, IMPM, and MRPM against total 300 clinical isolates of Escherichia coli, Klebsiella pneumoniae, and Psuedomonas aeruginosa and 134 Streptococcus pneumoniae collected from 5 different university hospitals. Using NCCLS guidelines, MICs of PAPM, IMPM, MRPM, and/or ceftazidime were determined.
Results: All isolates of E. coli and K. pneumoniae were susceptible to PAPM, IMPM and MRPM. MIC90 of PAPM, IMPM, and MRPM against P. aeruginosa were 32, 16, and 8 ㎍/mL, respectively. Comparing Mueller-Hinton agar (MHA) and minimal agar Davis (MAD), the MIC90 of PAPM and IMPM were reduced from 16 and 32 ㎍/mL to 8 and 8 ㎍/mL, respectively. PAPM was more influence by MAD than IMPM. All isolates of penicillin susceptible S. pneumoniae showed 0% of resistance to the carbapenems tested. MIC90 of PAPM, IMPM and PRPM against penicillin con-susceptible S. pneumoniae were 0.25, 1 and 2 ㎍/mL, respectively.
Conclusion: Painpenem could be one of the potentially useful drugs for the treatment of infections caused by E. coli, K. pneumoniae, and S. pneumoniae. We also showed that PAPM had good anti-pseudomonal activity when examined in MAD, the amino acid-limited media. Therefore, it could be useful for the treatment of infections caused by P. aeruginosa.
|
|
|
KEYWORD
|
|
|
panipenem, imipenem, meropenem, escherichia coli, klebsiella pneumoniae, pseudomonas aeruginosa, streptococcus pneumoniae, antimicrobial susceptibility
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
  
|
|